DACC Funding

FUNDING

DACC Grants Database:

The Department currently has 17 funded projects.

Investigator

Agency

Award

Funding Period

Steven Roth

NEI

NOT-EY-09-002

7/1/2009 - 2/28/2011

The Role of Adenosine in Retinal Ischemia

The Administrative Supplement will allow for necessary upgrades to the equipment in Dr. Roth's lab which will significantly enhance the ability to delevop inhanced mri of the retina to measure retinal ion regulation.

Daniel McGehee

NIH

5F31NS062524-02

7/1/2009 - 6/30/2010

Intrinsic amplification of synaptic inputs to nigral dopamine cells

The goal of this project is to determine which subtype (s) of TRP channels are highly expressed in the Substantia nigra dopamine neurons using quantitative RT-PCR.

Steven Roth

RAC-Internal

5/1/2009 - 4/30/2010

T o provide a stringent in vivo model for gene delivery utilizing human mesenchymal stem cells in the setting of retinal ischemia, an important clinical entity causing blindness. This project contains the possibility of using targeted stem cell therapy in an accessible region of the central nervous system.

Ming Xu

NIH

1 R01 DA025088-01A1

4/15/2009 - 3/31/2014

Extinction of cue-elicited cocaine seeking

The proposed work will identify how specific changes in neuronal circuits, cellular signaling and gene expression may facilitate the extinction of drug seeking behaviors. These experiments may provide potential new targets for pharmacological and molecular interventions for the treatment of drug abuse.

Steven Roth

IRI Pilot Program

2/16/2009 - 6/30/2009

Imaging the Optic Nerve

Support received for imaging studies on the pre-clinical MRI system from the University of Chicago BSD Imaging Research Institute.

Stephen Roth

Cancer Research Fnd

10/1/2008 - 9/30/2009

Animal Model of Perioperative Ischemic Optic Neuropathy: MRI Contrast-Enhanced Imaging of Neurotransmission in the In Vivo Rodent Optic Nerve

To establish a rat model of peri-operative ischemic optic neuropathy (ION) to examine mechanisms of axonal injury and to provide important new data to understand and prevent an important clinical problem that results in visual loss.

Chun-Su Yuan

NIH

9/30/2008 - 7/31/2013

Center for Herbal Research on Colorectal Cancer

The center project will focus on two selected botanicals, unsteamed and steamed American ginseng and notoginseng, against colorectal cancer. The overall goal of this center project is to characterize the anti-tumor activities and mechanisms of action of the two herbs and their active constituents.

Steven Roth

Brain Research Foundation

6/1/2008 - 5/31/2009

Rodent Model of perioperative ischemic optic neuropathy

To examine mechanisms of axonal injury using a clinically relevant model of perioperative visual loss and provide new insights into the mechanisms of axonal injury and also to provide clinically translatable data on perioperative visual loss that will alter the care we give our patients.

James Zacny

NIH

R01 DA23969

9/24/2007 - 6/30/2011

Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients

This application consists of a series of clinical laboratory studies to examine a potential modulator of abuse-related effects of prescription opioids that has relevance to the treatment of chronic nonmalignant pain. Our application seeks to determine if different adjuvant drugs that are commonly co-prescribed along with prescription opioids to chronic nonmalignant pain patients produce greater abuse liability-related effects (drug liking) than the prescription opioid alone. The studies have public health ramifications: if an adjuvant drug (e.g, muscle relaxant A) in combination with a prescription opioid produces greater abuse liability-related effects than the opioid alone, such information would be important for clinicians to have in that alternative efficacious adjuvant that do not show such enhancement (e.g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients.

Christopher Nemeth

HHS/AHRQ

P20 HS017124-01

9/1/2007 - 8/31/2009

Creating Safe Ambulatory Care: The Path to Resilience

The goal of this project is to assess and reduce potential harm to ambulatory care patients, in keeping with the 2005 NAE/IOM report "Building a Better Delivery System" recommendation to team human factors and health care expertise to improve the safety of the health care system.

Daniel McGehee

6/1/2007 - 5/31/2009

Corticospinal motor neuron degeneration in ALS: Protection by VEGF

The goal of this project is to test the hypothesis that vascular endothelial growth factor (VEGF) protects neurons in motor cortex in part by modifying expression of the glutamate receptors underlying excitotoxicity in ALS. Experiments in this project will test assess whether VEGF protects motor cortex neurons from glutamate excitotoxicity, and whether this occurs through modification of Ca2+-permeable AMPA receptor expression in motor cortex.

Chun-Su Yuan

NIH

R21 AT003255

5/1/2007 - 4/30/2009

Herbal Effects on Oxidant Dynamics in Cardiomyocytes

To evaluate two commonly used herbs with antioxidant properties that could be useful in cardiovascular disease, namely grape seed proanthocyanidin extract (seeds from Vitis vinifera grapes; GSPE) and Scutellaria baicalensis extract (SbE) Using two distinct antioxidant herbs will advance our understanding of whether different antioxidants induce distinct cellular responses.

More


DACC Grants Database:	The Department currently has 17 funded projects.

Investigator	Agency	Award	Funding Period

Steven Roth	NEI	NOT-EY-09-002	7/1/2009 - 2/28/2011
The Role of Adenosine in Retinal Ischemia
The Administrative Supplement will allow for necessary upgrades to the equipment in Dr. Roth's lab which will significantly enhance the ability to delevop inhanced mri of the retina to measure retinal ion regulation.

Daniel McGehee	NIH	5F31NS062524-02	7/1/2009 - 6/30/2010
Intrinsic amplification of synaptic inputs to nigral dopamine cells
The goal of this project is to determine which subtype (s) of TRP channels are highly expressed in the Substantia nigra dopamine neurons using quantitative RT-PCR.

Steven Roth	RAC-Internal		5/1/2009 - 4/30/2010

T o provide a stringent in vivo model for gene delivery utilizing human mesenchymal stem cells in the setting of retinal ischemia, an important clinical entity causing blindness. This project contains the possibility of using targeted stem cell therapy in an accessible region of the central nervous system.

Ming Xu	NIH	1 R01 DA025088-01A1	4/15/2009 - 3/31/2014
Extinction of cue-elicited cocaine seeking
The proposed work will identify how specific changes in neuronal circuits, cellular signaling and gene expression may facilitate the extinction of drug seeking behaviors. These experiments may provide potential new targets for pharmacological and molecular interventions for the treatment of drug abuse.

Steven Roth	IRI Pilot Program		2/16/2009 - 6/30/2009
Imaging the Optic Nerve
Support received for imaging studies on the pre-clinical MRI system from the University of Chicago BSD Imaging Research Institute.

Stephen Roth	Cancer Research Fnd		10/1/2008 - 9/30/2009
Animal Model of Perioperative Ischemic Optic Neuropathy: MRI Contrast-Enhanced Imaging of Neurotransmission in the In Vivo Rodent Optic Nerve
To establish a rat model of peri-operative ischemic optic neuropathy (ION) to examine mechanisms of axonal injury and to provide important new data to understand and prevent an important clinical problem that results in visual loss.

Chun-Su Yuan	NIH		9/30/2008 - 7/31/2013
Center for Herbal Research on Colorectal Cancer
The center project will focus on two selected botanicals, unsteamed and steamed American ginseng and notoginseng, against colorectal cancer. The overall goal of this center project is to characterize the anti-tumor activities and mechanisms of action of the two herbs and their active constituents.

Steven Roth	Brain Research Foundation		6/1/2008 - 5/31/2009
Rodent Model of perioperative ischemic optic neuropathy
To examine mechanisms of axonal injury using a clinically relevant model of perioperative visual loss and provide new insights into the mechanisms of axonal injury and also to provide clinically translatable data on perioperative visual loss that will alter the care we give our patients.

James Zacny	NIH	R01 DA23969	9/24/2007 - 6/30/2011
Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
This application consists of a series of clinical laboratory studies to examine a potential modulator of abuse-related effects of prescription opioids that has relevance to the treatment of chronic nonmalignant pain. Our application seeks to determine if different adjuvant drugs that are commonly co-prescribed along with prescription opioids to chronic nonmalignant pain patients produce greater abuse liability-related effects (drug liking) than the prescription opioid alone. The studies have public health ramifications: if an adjuvant drug (e.g, muscle relaxant A) in combination with a prescription opioid produces greater abuse liability-related effects than the opioid alone, such information would be important for clinicians to have in that alternative efficacious adjuvant that do not show such enhancement (e.g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients.

Christopher Nemeth	HHS/AHRQ	P20 HS017124-01	9/1/2007 - 8/31/2009
Creating Safe Ambulatory Care: The Path to Resilience
The goal of this project is to assess and reduce potential harm to ambulatory care patients, in keeping with the 2005 NAE/IOM report "Building a Better Delivery System" recommendation to team human factors and health care expertise to improve the safety of the health care system.

Daniel McGehee			6/1/2007 - 5/31/2009
Corticospinal motor neuron degeneration in ALS: Protection by VEGF
The goal of this project is to test the hypothesis that vascular endothelial growth factor (VEGF) protects neurons in motor cortex in part by modifying expression of the glutamate receptors underlying excitotoxicity in ALS. Experiments in this project will test assess whether VEGF protects motor cortex neurons from glutamate excitotoxicity, and whether this occurs through modification of Ca2+-permeable AMPA receptor expression in motor cortex.

Chun-Su Yuan	NIH	R21 AT003255	5/1/2007 - 4/30/2009
Herbal Effects on Oxidant Dynamics in Cardiomyocytes
To evaluate two commonly used herbs with antioxidant properties that could be useful in cardiovascular disease, namely grape seed proanthocyanidin extract (seeds from Vitis vinifera grapes; GSPE) and Scutellaria baicalensis extract (SbE) Using two distinct antioxidant herbs will advance our understanding of whether different antioxidants induce distinct cellular responses.